ICAM1 and cardiovascular disorder: Leukocytes play a major role in endothelial cell (EC) dysfunction and related cardiovascular diseases.8 Upregulation of adhesion molecules that include E-selectin, P-selectin, and intercellular adhesion molecule 1 (ICAM-1) on the EC surface in response to cytokine stimulation leads to increased leukocyte–endothelium interactions.