IRF4 and viral infectious disease: KSHV derived PAN RNA was proved in to interact with histone H1/H2A, single-stranded binding proteins (SSBPs) and interferon regulatory factor 4 (IRF4) in infected cells to decrease the expression of IFNγ, IFNα, interleukin-18, and RNase L to facilitate viral infection in primate cell lines (42).