TNF and neoplasm: Following recognition of major histocompatibility complex (MHC) class I-antigen complexes on tumor cell surface, activated CTLs induce tumor cell lysis by secreting perforin, granulysin and granzyme, as well as producing the death ligands including Fas Ligand (FasL) and tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) (7).