IFNG and glioblastoma: Although a recent study by Nduom et al. reported a median PD-L1 expression of 2.8% in their study of 94 GBM samples, robust induction of PD-L1, which is presumably due to local IFN-γ production, on GBM tissues was observed in the recent EGFRvIII-CAR clinical trial (12, 110).