CXCL10 and central nervous system cancer: We have also shown that adjuvant polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC) provided systemically can promote cytotoxic lymphocyte trafficking into gliomas in an IFN-α and IFN-γ dependent manner through induction of CXCL10 (44).