TYK2 and autoimmune disease: To gain better understanding of the function of TYK2P in cytokine signaling and autoimmune disease, we generated a knock-in mouse strain containing the identical amino-acid substitution in the murine TYK2 protein (Tyk2-P1124A), hereafter referred to as Tyk2P mice or as Tyk2NP/P and Tyk2P/P for heterozygous and homozygous animals, respectively (further detailed explanation of genotypes, please see Supplementary Table 1).