LNPEP and hypertensive disorder: Noteworthy, in Asia, where ERAP2 displays a minor degree of polymorphism, LNPEP variants have been described to correlate with the onset of autoinflammatory phenomena, as well as with susceptibility to hypertension: i.e., the A variant in LNPEP rs2303138, in East Asia (40% in Asia, 5–6% in the rest of the world) (Table 1) is in LD with the productive allele A in ERAP2 rs2248374, but correlates with a lower expression of LNPEP (63).