In conclusion, we have demonstrated that chronic IHH, which induces strong protection against arrhythmias occurring during acute I/R insult, is associated with increased expression, phosphorylation and redistribution of myocardial Cx43 as well as with increased anti-arrhythmic n-3 PUFA proportion in heart phospholipids persisting after brief ischemia. Here, GJA1 is linked to cardiac arrhythmia.