APP and Alzheimer disease: The results showed that MCs in APP/PS1 mice at 3–4 (p < 0.01, Figures 7A,B) and 9–10 months of age (p < 0.001, Figures 7C,D) displayed a relatively higher spontaneous firing rate of sAP than their age-matched control mice (Figures 7A–D), indicating the hyperactivation of MCs in both the early and late stage of AD.