In addition, the wild-type showed an increasing trend in the immobility time (pre: 50.86 ± 6.18, post: 68.57 ± 6.48, p > 0.05, paired t-test) post CFA injection compared to that prior to CFA injection, whereas Kcnip3-/- rats showed significantly increased immobility time (pre: 78.14 ± 7.98, post: 108.00 ± 7.06, p < 0.05, paired t-test), suggesting that Kcnip3-/- rats are more vulnerable to depression than wild-type rats. The gene discussed is KCNIP3; the disease is major depressive disorder.