Interestingly, overexpression of PKA has been observed to rescue PINK1 deficiency, so it is possible that PKA is in part regulating Mic60 in a manner similar and parallel to PINK1 (Dagda et al., 2011; Kostic et al., 2015) The significance of these pathways to PD pathology, or their relevance to one another, remains to be elucidated. This evidence concerns the gene PINK1 and Parkinson disease.