IMMT and amyotrophic lateral sclerosis: Indeed, Mic60 has previously been linked to neurological disorders, including fetal Down syndrome (Bernert et al., 2002; Myung et al., 2003), seizure (Omori et al., 2002; Furukawa et al., 2011), schizophrenia (Millar et al., 2005; Park et al., 2010; Atkin et al., 2011), Amyotrophic Lateral Sclerosis (ALS) (Fukada et al., 2004), optic atrophy (Abrams et al., 2015; Abrams et al., 2018), and neurodegeneration in animal models (Wang et al., 2008).