IMMT and obesity due to melanocortin 4 receptor deficiency: Studies in patients and models have also linked Mic60 with obesity, diabetes, osteoporosis, and cardiac dysfunctions (Baseler et al., 2011; Guo et al., 2013; Gutierrez-Salmean et al., 2014; Gorr and Wold, 2015; Lindinger et al., 2015; Wang et al., 2017; Lv et al., 2018), and upregulation of Mic60 has shown to be protective in models of diabetes and osteogenesis (Thapa et al., 2015; Lv et al., 2018).