The correlation between RPSA expression and tumour aggressiveness proposes RPSA as a promising strong target in fight against cancer but also in prion diseases and Alzheimer’s disease.18 Therefore, by its multiple functions like maintenance of nuclear structures and translational processes, RPSA knockdown by siRNAs or CRISP-Cas9 approaches to elucidate whether or not targeting of RPSA significantly reduce tumour cell migration and invasion constitute a challenge. This evidence concerns the gene RPSA and prion disease.