There were significant downregulations of BRM, IκB, Foxf1, and ITIH-5 expression in the peri-infarct area of the cortex of stroke-EPC animals compared to stroke-vehicle animals at 7 days post EPC transplantation (Student t-test; p’s < 0.05) (Fig. 5a, b). This evidence concerns the gene ITIH5 and stroke disorder.