Spontaneous feline oral squamous cell carcinoma (FOSCC) and head and neck squamous cell carcinoma (HNSCC) in humans share molecular markers (EGFR, VEGF, and p53), tumour biology, treatment and prognostic similarities [122, 123], with both showing comparable rates of development of metastasis (15–20%) [124]. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.