Although limb ischemic conditioning (3/12, 25%) was not as effective as liver preconditioning (1/12, 8%; P = 0.0433 vs. Kcne2‐/‐ control mice) in reducing the incidence of AVB, both liver and limb conditioning exerted a striking cardioprotective effect against SCD in Kcne2‐/‐ mice (5 death/15 Kcne2‐/‐ control mice, compared to 0 death/12 RIPC‐liver‐ or limb‐treated Kcne2‐/‐ mice; P = 0.047) (Fig. 3A). The gene discussed is KCNE2; the disease is Schnyder corneal dystrophy.