The calpain system has been confirmed to play an important role in influencing ovarian cancer patient outcomes with the adverse association between high calpain-2 expression and worse overall survival in ovarian cancer (Storr et al. 2012) being recently verified, and with calpain-4 and calpastatin expression also being found to be associated with overall survival (Zhang et al. 2018). The gene discussed is CAST; the disease is ovarian carcinoma.