Low Syk-c, low Syk-n and low MAP4 showed significant association with organ-confined status of tumour (Syk-c: χ2 = 9.975, df = 1, P = 0.002; Syk-n: χ2 = 4.169, df = 1, P = 0.041; and MAP4: χ2 = 15.402, df = 1, P = 0.000087), whereas no significant association was detected between protein expression and cancer distant metastasis. This evidence concerns the gene SYK and cancer.