The drug sensitivity profile of ovarian cancer paclitaxel-resistant sublines parallels the regulation of MAP4 modification: MAP4 phosphorylation and dissociation from microtubules decrease the sensitivity of paclitaxel-resistant ovarian cell lines towards paclitaxel (Poruchynsky et al. 2001; Orr et al. 2003). The gene discussed is MAP4; the disease is ovarian carcinoma.