Because NMRAL2P has been shown to be involved in the nuclear factor erythroid 2 like 2 (NRF2) pathway, in which NRF2 regulates NMRAL2P expression and NMRAL2P subsequently regulates expression of NQO1 [36–38], we next evaluated whether THC affected NRF2 activation and NQO1 expression in ESCC cells. The gene discussed is NFE2L2; the disease is esophageal squamous cell carcinoma.