In addition, we examined the basal KEAP1 mRNA expression level or nuclear NRF2 protein level in ESCC cells, and we assessed the correlation between their expression levels and their differentiation status, morphological phenotype, and sensitivity to THC (Supplementary Tables 1, 2 and Supplementary Fig. 5a, b). This evidence concerns the gene NFE2L2 and esophageal squamous cell carcinoma.