MYC and myelodysplastic syndrome: Conversely, RNA-seq analyses of MDS HSPC treated or not treated with anti-PD-1 for 48 h revealed a decrease in MYC target genes following treatment with anti-PD-1, along with increases in the expression of genes involved in heme metabolism and IL2/STAT5 signaling, as would be expected with improvements in hematopoiesis (Fig. 7c, and Supplementary Figure S7a).