These findings have been validated by others in alternate models, namely deletion 5q (del[5q]) MDS and the Rps14-haplodeficient murine model, whereby S100A9 and S100A8 (calprotectin), the heterodimeric binding partner of S100A9, trigger erythroid progenitor cell death [28]. The gene discussed is S100A8; the disease is myelodysplastic syndrome.