Interestingly, Myc is a major regulator of tumor cell metabolism, and here we have found that BM-MNC of MDS patients and healthy BM-MNC treated with rhS100A9 express elevated Myc levels, and that MDS patients and S100A9Tg mice display features of metabolic syndrome [38], including hyperglycemia in the BM niche. This evidence concerns the gene MYC and metabolic syndrome.