After DNA sequencing, the Hurler disease patient A, presented as homozygous for the founder (nonsense) variant c.208 C > T, p.(Gln70*) in exon 2 of the IDUA gene (chromosome 4p16.3) known to occur in patients with Hurler disease in a homozygous or compound heterozygous state. This evidence concerns the gene IDUA and Hurler syndrome.