Moreover, since TS is a common anti-cancer drug target, being required for DNA repair and directly inhibited by compounds like pyrimidine or folate analogues [23], we additionally tested if change in TS expression altered BC cells’ sensitivity to the anti-folate drug pemetrexed and to cisplatin, in a similar fashion as previously observed in NSCLC [19] [24]. The gene discussed is TYMS; the disease is breast cancer.