Multivariate-adjusted linear regression analysis demonstrated that one-SD increases of circulating HSPCs frequency, serum CRP level, white blood cell count and neutrophil count were associated with 2.33% (95% CI, −4.61% to −0.06%; p = 0.045), 3.04% (95% CI, −5.65% to −0.44%; p = 0.023), 1.92% (95% CI, −3.28% to −0.56%; p = 0.007) and 2.25% (95% CI, −3.58% to −0.09%; p = 0.01) declines of left ventricular ejection fraction in CHD patients, respectively. Here, CRP is linked to coronary artery disorder.