HSP90B2P and hereditary spastic paraplegia: In our analysis, the CMT2 and HSP LCCs are significantly larger than expected by random chance (CMT2: n = 35, z-score = 17.1; HSP: n = 16, z-score = 4.0) (Fig. 1A,C), indicating that the CMT2 and HSP disease proteins form disease proto-modules composed of proteins with high biological and functional similarity.