Among these, the genes involved in the Toll-like receptors (TLR) and NOD-like receptors (NOD) signaling pathways (i.e., TLR4, TLR5, CARD6, NOD1 and NLRP1, et al.)were significantly reduced in ovarian cancer tissues, while other genes increased in ovarian cancer tissues (i.e., TLR6, MYD88 and NLRP3, et al.)(Fig. S4). The gene discussed is TLR5; the disease is ovarian cancer.