Among these, the genes involved in the Toll-like receptors (TLR) and NOD-like receptors (NOD) signaling pathways (i.e., TLR4, TLR5, CARD6, NOD1 and NLRP1, et al.)were significantly reduced in ovarian cancer tissues, while other genes increased in ovarian cancer tissues (i.e., TLR6, MYD88 and NLRP3, et al.)(Fig. S4). This evidence concerns the gene CARD6 and ovarian cancer.