Interestingly, we noticed that six distinct regulatory SNPs (rs1801311, rs2269524, rs28633410, rs5751195, rs6002621 and rs8135801) showed significant association with the expression of FAM109B gene (Supplementary Table 5 and Table 1), indicating that these SNPs may confer risk of schizophrenia through modulating FAM109B expression. The gene discussed is PHETA2; the disease is schizophrenia.