CACNA1C and schizophrenia: However, considering that some of the schizophrenia-associated variants are located in human-specific (or accelerated) region36,37 (e.g., a recent study showed that a human-specific tandem repeat in intronic region of CACNA1C have pivotal role in schizophrenia susceptibility36), it is challenging for these annotation methods to prioritize the potential functional SNPs located in these human-specific regions.