However, the number of CTCF binding–disrupting SNPs (observed in this study) were not significantly different from random SNPs (P > 0.05, 1000 simulations, Supplementary Fig. 10b), implying that the frequent disruption of CTCF by schizophrenia risk SNPs may be due to random effect. The gene discussed is CTCF; the disease is schizophrenia.