Both the experimental FZD6 R416A6.32 and the naturally occurring cancer mutants of the molecular switch R416Q6.32 and W493L7.55 were impaired in the ability to recruit DVL to the membrane and to induce the electrophoretic mobility shift associated with DVL activation (Fig. 4a–c and Supplementary Figure 7)50,51. This evidence concerns the gene FZD6 and cancer.