IL17A and colitis: To determine if dysregulation in IL17 driven gut humoral response promotes colitis in NikΔIE mice, Jh−/− mice on 2% DSS for 3-days were transplanted with B-cells isolated from the PP of WT, NikΔIE, RankΔIE, and Il17−/− mice and DSS treatment was continued for additional 4 days (Fig. 5c).