Our western blotting data demonstrated that the expression of XIAP or RICTOR is decreased in CRC cell lines SW620 and LoVo treated with miR-500a-5p (Supplementary Fig. 7a), whereas it is increased in the normal human colon epithelial cells FHC and NCM460 transfected with the miR-500a-5p inhibitor (Supplementary Fig. 7b). Here, XIAP is linked to colorectal carcinoma.