To explore the relationship between miR-500a-5p molecule and the YY1/p300/HDAC2 complex, the CRC cells were transfected with expression plasmids of the vector YY1, HDAC2, and p300, alone or in combination with YY1 + p300, HDAC2 + p300, and YY1 + HDAC2 + p300, respectively, for 48 h. This evidence concerns the gene HDAC2 and colorectal carcinoma.