Consistent with the accumulation of cells in the G0/G1 phase, the expression of Cyclin D1, CDK4 and CDK6 was significantly decreased in the miR-500a-5p mimic-treated CRC cells, whereas that of Cyclin B1 remained unchanged compared with its expression in the m-NC-treated cells (Supplementary Fig. 4b). The gene discussed is CCND1; the disease is colorectal carcinoma.