HDAC2 and neoplasm: In addition, the mice injected with LoVo/HDAC2 cells developed larger tumours than those injected with LoVo/Vector and LoVo/miR-500a-5p cells, whereas the LoVo/miR-500a-5p/HDAC2 cells formed smaller xenograft tumours than did LoVo/HDAC2 cells (Fig. 4a, b).