Moreover, the LoVo/HDAC2 group rapidly proliferated and tumour vessel density increased compared with the LoVo/Vector and LoVo/miR-500a-5p cell groups, whereas LoVo/miR-500a-5p/HDAC2 inhibited the growth rate and tumour vessel density in the LoVo/HDAC2 group (Fig. 4d, f). This evidence concerns the gene HDAC2 and neoplasm.