PJA1 and central nervous system cancer: However, in IDH-mutant 1p/19q co-deleted low-grade gliomas (LGG) mean PJA1 expression is not statistically different between the CIC mutant versus CIC wild-type group, which is likely due to genetic loss of CIC and lack of hyperactive Ras/ERK signaling in these tumors (Supplementary Figure 5G).