CFTR and cystic fibrosis: Mice bearing a knockout of CFTR (genotype: Cftr−/−) or a loss-of-function mutation frequently occurring in human CF (genotype: CftrF508del/F508del) exhibited signs of intestinal inflammation, including a local increase in IL-15 mRNA expression, that could be increased by oral challenge with gliadin (in CftrF508del/F508del mice).