Tumor Treg cells upregulate the exhaustion marker Lag3 (Malik et al., 2017), as well as Cxcr3 and Ccl5, while control skin Treg cells upregulate skin Treg cell markers such as Il1rl1, Pim1, Sdc4, Kdm6b, and Erdr1. However, skin Treg cell signature genes such as Batf, Tnfrsf4, Tnfrsf9, Samsn1, Tigit, Tchp, Ccr8, Ccr2, and Itgav are similarly expressed in both populations. Here, TIGIT is linked to neoplasm.