Consistently, we categorized 32 ESCC tissues by the level of CD44 expression (strong≥50%; 50% > medium≥20%; weak< 20%) and FMR1-AS1 and c-Myc were both observed much higher expression in the CD44 strong staining tissues than in the CD44 medium and weak samples (Fig. 5k, l). This evidence concerns the gene CD44 and esophageal squamous cell carcinoma.