FMR1 and esophageal squamous cell carcinoma: And this result was confirmed in the validation set (Guangzhou: 188, HR = 1.768; 95%CI = 1.189–2.631; P = 0.0031) and the pooled set (HR = 1.679; 95%CI = 1.28–2.202; P = 0.0001), the high FMR1-AS1 group showed a lower OS of female ESCC patients (Fig. 1f, Additional file 3: Figure S1d and Additional file 4).