FMR1 and esophageal squamous cell carcinoma: Our results revealed the function of exosomal FMR1-AS1 in maintaining ESCC CSC dynamic interconversion and the possible mechanism of its action, which shed light on the functional exosomal lncRNAs might be taken as attractive targets for ESCC precision therapeutics and improved the understanding how CSCs and non-CSCs cell states coexist, transmit and evolve within tumors that may futher facilitate the development of more effective therapies.