Moreover, the silencing of MyD88 could also hinder the NFκB-c-Myc signaling cascades and phenotype transition through FMR1-AS1 exosome incubation in the ESCC cells (Fig. 6d-f, Additional file 11: Figure S6b and Additional file 4). The gene discussed is FMR1; the disease is esophageal squamous cell carcinoma.