We further characterized the CD11b + CD14 + CD33 + CD11c + myeloid populations for expression of HLA-DR, the Major Histocompatibility Complex (MHC) class II molecule that is downregulated on certain subsets of myeloid cells, including monocytic and early myeloid-derived suppressor cells, that are often associated with tumor suppressive phenotype [32, 35]. The gene discussed is CD33; the disease is neoplasm.