To further determine the role of the IL-11/GP130/STAT3 pathway inhibition in colon cancer treatment with bazedoxifene, DLD-1, HCT-116 and HCT-15 cells were transfected with IL-11R siRNA for 48 h and treated with bazedoxifene for another 24 h. The gene discussed is STAT3; the disease is malignant colon neoplasm.