It can be inferred from this present study that the observed decrease in SIRT1 and SIRT3 levels in our model may be, at least in part, due to oxidative stress, although we found a nonsignificant increase in lipid peroxidation in the T2D group and no difference in TBARS level between the T1D and control groups. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.