While the inhibition of the inflammasome transcripts by L. amazonensis parasites and the role playing by the osteopontin are intriguing; additional investigation is required i) to demonstrate if the OPN implication represents a direct effect or an effect requiring the regulation of other molecules and ii) to identify the in vivo cell types implicated and the exact mechanisms involved: thus novel strategies to control L. amazonensis parasites infection may be revealed. This evidence concerns the gene SPP1 and infection.