Because macrophages are well-known to be fusogenic [3] and several studies showed that macrophages could fuse with cancer cells in in vitro and in vivo animal studies [9,10,12,15], macrophage markers, such as CD14, CD45 and CD163, have primarily been used for the search of TN-hybrid cells in human tumors [13,20,29,35,36,41,42]. The gene discussed is CD163; the disease is cancer.