Germline adenomatous polyposis coli (APC) mutations represents the genetic basis of familial adenomatous polyposis (FAP); more than 60% of sporadic CRC cases have genetic alterations in the APC gene leading to stimulation of the Wnt/β-catenin pathway, which drives tumor initiation and recurrence [8]. This evidence concerns the gene APC and Familial adenomatous polyposis.