VEGFA and glioblastoma: Here, we demonstrate the physical interaction between circSMARCA5 and the splicing factor SRSF1 in GBM cells; based on our data, we propose that this interaction regulates the switch between pro- and anti-angiogenic isoforms generated by the splicing of the clinically relevant Vascular Endothelial Growth Factor A (VEGFA) pre-mRNA in GBM cells.