TAC1 seems to involve mainly type 2 asthma including allergic (higher expression of IL-13/TH2 signatures) and non-allergic ILC2-mediated (higher expression of ILC2 signatures) eosinophilic asthma, which closely resembles the pathobiology of the fungi-induced (e.g., Aspergillus and Alternaria species) severe eosinophilic murine asthma model (i.e., related to IL-13/TH2 and ILC2 signatures, prominent tissue eosinophilia, upregulation of genes associated with epithelium-derived cytokine such as IL-33 and TSLP). This evidence concerns the gene IL33 and Increased total eosinophil count.