Interestingly, there were increased mixed type 1/type 17 immune responses in a background of type 2 inflammation (i.e., increases in IFN-γ/IL-17/type 2 cytokines including IL-4, IL-5, and IL-13) of the lungs from OVALPS-OVA mice, implying that this murine model may represent a typical endotype of non-type 2 severe asthma. Here, IL4 is linked to asthma.