Patients with severe asthma possess more IFN-γ-positive and IL-17A-positive CD4-positive T cells in BAL cells [40] and increased production of both IL-17A and IFN-γ by CD8-depleted PBMCs from patients with CS-resistant asthma compared with patients with CS-sensitive asthma [41]. The gene discussed is IFNG; the disease is asthma.