NLRP3 and asthma: Meanwhile, we have recently demonstrated that mtROS-mediated NLRP3 inflammasome activation in airway epithelium is also critically implicated in Af-induced CS-resistant eosinophilic asthmatic features [74], highlighting the potential of ER stress–mtROS-mediated NLRP3 inflammasome activation in airways as a unique endotype of severe asthma, irrespective of predominant airway inflammatory cell phenotypes.