Some examples are: CAR T-cells directed against carbonic anhydrase IX (CAIX) in renal cell cancer resulted in hepatotoxicity due to the expression of CAIX on bile duct epithelium [55,56], ERBB2 CAR T-cells used in metastatic colorectal cancer caused pulmonary toxicity due to antigen expression on lung epithelium along with multi-organ failure and ultimate demise of patient. This evidence concerns the gene CA9 and metastatic colorectal cancer.