APP and Alzheimer disease: Drosophila offers a powerful in vivo model to study the Aβ-induced toxicity, because transgenic expression of the human pathogenic fragment of APP (Aβ1–42) recapitulates the majority of pathological hallmarks of AD, including neurotoxicity, nuclear inclusion formation, age-dependent neurodegeneration, locomotor dysfunction and early death [50,51,52,53,54].