ITGB1 and renal cell carcinoma: The silencing of TG2 expression in primary site A-498 and Caki-2, and metastatic site Caki-1 and ACHN RCC cell lines was found to cause a disruption in the organization of actin cytoskeleton organization, as well as a reduction in the attachment and spreading of all cell lines on ITGB1 substrates [134].