Being one of the key oncogenic molecules in RCC, HIF-1α is responsible for regulating the expression of genes involved in EMT, angiogenesis, and glycolysis, thence TG2-mediated activation of HIF-1α may explain the promotion of EMT [55] and metastatic phenotype [134] by TG2 in RCC. The gene discussed is TGM2; the disease is renal cell carcinoma.