Nevertheless, the mechanism for recruitment of podoplanin-expressing lymph node stromal cells in the tumor microenvironment is not known, and the nature of the cell(s) responsible for these effects is also an unsolved question, since podoplanin-expressing lymph node stromal cells are likely composed of a heterogeneous mixture of FRCs, LECs, and Th17 cells. Here, PDPN is linked to neoplasm.