To reveal the relationship between HFD-induced inflammation and tumor progression in the prostate, we used two genetically-engineered prostate cancer mouse models, prostate-specific Pten knockout mice (Pb-Cre+; Pten(fl/fl)) and Pten and Tp53-double knockout mice (Pb-Cre+; Pten(fl/fl); Tp53(fl/fl)) on the C57BL/6 genetic background. This evidence concerns the gene TP53 and Familial prostate cancer.