Tumor-infiltrating B cells produce lymphotoxin, a cytokine belonging to the TNF family, that leads to activation of IκB kinase α and STAT3, which promote the survival and proliferation of androgen-deprived prostate cancer cells that result in the development of a castration-resistant state in experiments using the TRAMP mice model [68]. The gene discussed is STAT3; the disease is Familial prostate cancer.