EDN1 and heart failure: Thus, cardiac troponin is related to myocardial necrosis; endothelin 1 is secreted by endothelial cells and correlates with shear stress; natriuretic peptides of myocardial stress (proBNP and proANP) are considered of similar accuracy for the diagnosis of heart failure); proADM is a neurohormonal biomarker of pressure and volume overload in heart failure.