Frequently TAMS and TANS are polarized towards a pro-tumor phenotype, M2 and N2, and in combination with Tregs produce immunosuppressive cytokines/ligands including transforming growth factor β (TGF-β), IL-4, arginase, reactive oxygen species, and programmed death ligand-1 (PD-L1) [94]. The gene discussed is TGFB1; the disease is neoplasm.