To disentangle effects of obesity-related inflammation from other demographic and health-related variables, and to study the potential link with risk factors of LOAD, information about education, hypertension, alcohol consumption, physical activity, APOE genotype and family history of dementia were also collected and included in the analysis (Dommermuth and Ewing, 2018; Ricci et al., 2017) (Table 1). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.