Because mutated Alsin proteins were responsible of the juvenile form of familial ALS2 disease (amyotrophic lateral sclerosis 2) [74], it should be interesting to ask if Drosophila ALS2 can influence vesicular Rab5 production or basal autophagy rate in neuronal cells. The gene discussed is ALS2; the disease is amyotrophic lateral sclerosis type 2, juvenile.