Because mutated Alsin proteins were responsible of the juvenile form of familial ALS2 disease (amyotrophic lateral sclerosis 2) [74], it should be interesting to ask if Drosophila ALS2 can influence vesicular Rab5 production or basal autophagy rate in neuronal cells. This evidence concerns the gene RAB5A and amyotrophic lateral sclerosis type 2, juvenile.