To test the relevance of CX43 for sepsis outcome, we compared our MAC-CX43 KO mice (Lyz2cre/cre, Gja1flox/flox) to mice heterozygous for the lyzozyme two cre sequence (Lyz2cre/wt, Gja1flox/flox) with or without pharmacological inhibition with Gap27 as well as sham operated controls. The gene discussed is GJA1; the disease is Sepsis.