A relevant role of neutrophils can be excluded, first, because of limited expression of CX43 in response to sepsis (Figures 2 and 3) and because no alterations of myeloperoxidase activity in the liver of mice 10 hr after CLP was observed in response to CX43 blockade (Figure 5—figure supplement 3E–F). The gene discussed is GJA1; the disease is Sepsis.