In addition, the suppression of these genes expression in A549, TGBC24TKB, and LK‐2 cells was stronger than that in BEAS‐2B cells, which are human normal lung cells with low Nrf2 activity (average expression of the seven genes: 49%, 51%, 70%, and 89%, respectively).13 Therefore, these results indicate that K‐563 inhibited the expression of Keap1/Nrf2 pathway downstream target genes in human cancer cells harboring Keap1 or Nrf2 mutations. This evidence concerns the gene NFE2L2 and cancer.