Further investigations will be required to clarify whether the other compounds in this natural product family do indeed induce Keap1/Nrf2 pathway inhibition or exert anti‐proliferative effects against cancer cells harboring Keap1 or Nrf2 mutations, as well as to discover new analogue compounds with Keap1/Nrf2 pathway inhibitory activity. Here, NFE2L2 is linked to cancer.