In Nrf2 knockout mice, Nrf2 deletion caused hemolytic anemia due to splenomegaly and spleen toxicity or resulted in impaired protection against xenobiotic toxicity.40, 41 Further in vivo studies in mice are needed to investigate not only the anti‐tumor effects, but also the toxicity of Keap1/Nrf2 pathway inhibitors, such as their blood toxicity and the detoxification of oxidative stress. This evidence concerns the gene NFE2L2 and neoplasm.