NF1 and cancer: Importantly, NF1‐associated tumors had significantly more mast cells than sporadic ones (more than 5 cells in about 50% and 30%, respectively).36 Although it is not possible to directly compare these studies because of different counting and immunolabeling methods, our results corroborate the low MCD in MPNSTs, as demonstrated by Friedrich et al,35 indicating that mast cells are potentially less relevant in the progression of malignant tumors.